CSN: Bullpen again fails Phillies in loss to Pirates

BOX SCORE

For the second time in less than 24 hours, the Phillies coughed up a lead in the late innings.

This time instead of the bullpen being the lone culprit, starting pitcher Cliff Lee had a hand in matters when he couldn?t get the third out in the seventh inning in the Phils? 6-4 loss to the Pirates on Thursday afternoon at Citizens Bank Park.

For the Phillies (9-14), it was their third straight loss to the Pirates and fourth loss in the last six games. It's the Phillies' first-ever series loss to the Pirates at Citizens Bank Park.

Starting pitching report
Lee needed 122 pitches to get through seven innings. Though he had seven strikeouts with just one walk, Lee ran into trouble in the seventh inning where he coughed up a two-run lead. With two outs and one on, Lee allowed three straight singles as the Pirates tied the game.

Lee allowed three runs on 10 hits. He did not have a single 1-2-3 inning.

Pirates? starter James McDonald faced three hitters in the sixth inning, allowing two hits and a walk. Up until that point he had allowed just three hits and a run in five innings.

McDonald received a no-decision, allowing three runs on five hits and three walks in five innings. He struck out four.

Bullpen report
It didn?t go well for the Phils? relievers. Phillippe Aumont started the eighth inning and retired just one hitter. The big right-hander allowed three runs on three hits before turning it over to veteran Chad Durbin.

Durbin got the last two outs of the inning, but not before he walked a pair and gave up a sacrifice fly.

The Pirates got a pair of relief innings from Justin Wilson and Tony Watson. The lefty Watson picked up his first career save.

At the plate
Ryan Howard had a pair of hits, including a double, and drove in two of the Phillies? runs. Dom Brown also had a pair of doubles and RBIs.

Otherwise, the Phillies failed to cash in on plenty of chances, going 2 for 15 with runners in scoring position.

For the Pirates, Gaby Sanchez in the sixth hit his second homer of the series. He also singled in a pair of runs. Meanwhile, pinch-hitter Garrett Jones hit a bases-loaded double in the eighth to put the Pirates ahead for good. Pitcher James McDonald added a pair of singles.

Outta here
Manager Charlie Manuel was ejected from the game by third-base ump Dan Iassogna in the ninth inning.? It was Manuel?s first ejection of the season.

Up next
The Phillies head to New York for a three-game series against the Mets on Friday night. Kyle Kendrick (1-1, 3.28) is slated to take on righty Dillon Gee (1-3, 5.95) in the opener.

In Saturday?s matinee, Jonathan Pettibone (0-0, 3.38) will make his second big-league start against Shawn Marcum (season debut). The series concludes on Sunday afternoon when Cole Hamels (0-3, 5.40) faces lefty Jonathan Niese (2-1, 3.81).

Source: http://www.csnphilly.com/baseball-philadelphia-phillies/instant-replay-pirates-6-phillies-4

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Drafts Adds Management Options, Better Evernote Integration, and More

iPhone/iPad: Drafts is one of our favorite mobile note-taking apps, and an update this morning adds a slew of new features, including some new organization options, integration with the Reminders app, and more.

If you haven't used Drafts before, its power lies in the fact that it can send text to just about any other app. It's essentially a starting point for all your notes. The big additions with this update are for organization. You can now organize notes into an inbox, archive, or pinned tab. You can also organize actions (like "send to Evernote") into different tabs as well. Essentially, it cleans up Drafts and makes it a bit easier to use. Speaking of Evernote, the Evernote integration goes even further, and you can now append notes to Evernote, easily create a new notebook, and more (check out the developer's guide for more on the new Evernote actions).

A bunch of other minor features have also been added, including full integration with the iOS Reminders app, improved text expander support, and a new keyboard on the iPad. It's a huge update, so check out the developers site for the full list and a few guides to the new features. If you're new to Drafts, be sure to look at our starter guide.

Drafts for iPhone ($2.99) | iTunes App Store

Drafts for iPad ($3.99) | iTunes App Store

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/3ShsOfg8TsE/drafts-adds-management-options-better-evernote-integra-479525281

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No Evidence That New Bird Flu Passes Between People: Study ...

THURSDAY, April 25 (HealthDay News) ? A new study is the first to confirm that the H7N9 bird flu virus is passed from birds to people. But the study did not find evidence of person-to-person transmission.

In the study, Chinese scientists provide details about four cases of human H7N9 infection in the eastern Zhejiang province. All four patients had been exposed to poultry, either through their jobs or by visiting poultry markets.

The study authors tested samples taken from 20 chickens, four quails, five pigeons and 57 ducks at six poultry markets where the patients were likely to have been. Two of the five pigeons and four of the 20 chickens tested positive for H7N9, but the virus was not found in any of the ducks or quails tested.

Then researchers analyzed the genetic makeup of H7N9 viruses from one of the patients and one of the chickens and found similarities between the viruses, confirming that the H7N9 virus can be transmitted from poultry to people, according to the study published online April 25 in The Lancet.

The scientists also tracked 385 family members, co-workers and health care staff who had unprotected contact with the patients. None of them showed any symptoms of H7N9 infection over 14 days of follow-up, which suggests that the virus currently cannot be spread among people.

However, there is evidence that the H7N9 virus has developed some genetic characteristics that adapt it specifically to infection in mammals. Further genetic changes might enable the virus to be transmitted from person-to-person, the researchers noted.

?Overall, the evidence, in terms of epidemiology and virology, suggests that it is a pure poultry-to-human transmission, and that controlling [the epidemic in humans] will therefore depend on controlling the epidemic in poultry,? study co-lead author Kwok-Yung Yuen, of the University of Hong Kong, said in a Lancet news release.

That would include measures such as temporary closure of live bird markets, comprehensive programs of surveillance, culling and segregation of poultry species, and possibly vaccination of poultry.

World Health Organization (WHO) officials said Wednesday that they are concerned about the ability of the H7N9 virus to jump from birds to humans and to infect birds without causing obvious symptoms, according to the Associated Press.

?This is definitely one of the most lethal influenza viruses we have seen so far,? Dr. Keiji Fukuda, the top influenza expert at WHO, said during a briefing in Beijing. However, a large number of milder cases may also be going undetected, he added. WHO officials investigated the H7N9 cases with Chinese authorities this week, the AP reported.

More than 100 people in China have been infected with the H7N9 virus, with most getting seriously sick and more than 20 dying, the AP noted. The first case in Taiwan was confirmed on Wednesday, a 53-year-old man who became sick after returning from a visit to the eastern Chinese province of Jiangsu.

More information

The U.S. Centers for Disease Control and Prevention has more about the H7N9 virus.

Source: http://news.health.com/2013/04/25/no-evidence-that-new-bird-flu-passes-between-people-study/

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Former ricin suspect: 'I love this country'

By Robbie Ward

TUPELO, Mississippi (Reuters) - U.S. prosecutors dropped charges on Tuesday against a Mississippi man accused of sending ricin-laced letters to President Barack Obama, a U.S. senator and a state judge, according to court documents.

The surprise decision came hours after Paul Kevin Curtis was released from a Mississippi jail on bond.

Prosecutors said the "ongoing investigation has revealed new information," but provided no additional details, according to the court order dismissing the charges.

Curtis told reporters he respected Obama. "I would never do anything to pose a threat to him or any other U.S. official," he said. "I love this country."

He said he had no idea what ricin was. "I thought they said 'rice,' I told them I don't eat rice," he said.

Curtis, who is 45 and known in Mississippi as an Elvis impersonator, had been released from jail on bond earlier on Tuesday after a judge indefinitely postponed a court hearing on his detention. The case was later dismissed "without prejudice," meaning the charges could be potentially reinstated if warranted.

Later on Tuesday federal law enforcement officials searched the house of a second Mississippi man, Everett Dutschke, Lee County Sheriff Jim Johnson told Reuters.

It was not clear if the search was related to the ricin case.

A representative for the U.S. Attorney's Office in Oxford, Mississippi, did not return calls for comment.

Dutschke is "cooperating fully" with the FBI, his attorney Lori Nail Basham told the Northeastern Mississippi Daily Journal. Dutschke has not been charged in the ricin case, she said.

Basham said Dutschke and Curtis were acquaintances and believed the two men had known each other for several years.

Deborah Madden, an FBI spokeswoman in Jackson, Mississippi, declined to comment. Phone calls to a number listed for Dutschke and his attorney went unanswered.

In 2007, Dutschke ran unsuccessfully as a Republican candidate against Stephen Holland, an incumbent Democratic state representative from the Tupelo area. Holland's mother, Sadie, is the judge to whom one of the ricin-tainted letters was mailed this month.

During the state campaign Dutschke produced a video titled "The Aliens are Coming," attacking his opponent for being soft on immigration, which stated that Holland was a "friend" of the September 11 hijackers.

LAWYER SAYS CURTIS WAS FRAMED

Christi McCoy, Curtis's attorney, told CNN she believed her client had been framed.

"I do believe that someone who was familiar and is familiar with Kevin just simply took his personal information and did this to him," McCoy told CNN. "It is absolutely horrific that someone would do this."

Curtis was arrested on April 17 at his home in Corinth, Mississippi. He was charged with mailing letters to Obama, Republican U.S. Senator Roger Wicker of Mississippi and Sadie Holland containing a substance that preliminarily tested positive for ricin, a highly lethal poison made from castor beans.

The letters were intercepted by authorities before they reached their destinations. The poison scare put Washington on edge during the same week the Boston Marathon bombing occurred.

Over the weekend, investigators searched Curtis's home, his vehicle and his ex-wife's home, but failed to find any incriminating evidence, McCoy told the Northeast Mississippi Daily Journal.

In a statement last week, Curtis's family said they had not been shown any evidence of the charges against him. They said he suffers from a long history of mental illness.

Typewritten on yellow paper, the three letters contained the same eight-line message, according to an affidavit from the FBI and the Secret Service filed in court.

"Maybe I have your attention now / Even if that means someone must die," the letters read in part, according to the affidavit. The letters ended: "I am KC and I approve this message."

The initials "KC" led law enforcement officials to ask Wicker's staff if they were aware of any constituents with those initials, and the focus of the investigation then turned to Curtis, the affidavit said.

Also on Tuesday, a Pentagon spy agency said tests found no suspicious letters after an alert during a screening of incoming mail at a military base in Washington, D.C.

Earlier on Tuesday, the Defense Intelligence Agency had said security personnel detected a potentially harmful substance during routine screening of incoming mail at Joint Base Anacostia-Bolling in Washington, and initial tests indicated the presence of "possible biological toxins."

(Additional reporting by David Adams, Tom Brown, Phil Stewart, David Lawder, Emily LeCoz; Writing by Kevin Gray; Editing by Jane Sutton, Gerald E. McCormick, Andre Grenon, Dan Grebler and Mohammad Zargham)

Source: http://news.yahoo.com/u-drops-charges-against-mississippi-man-ricin-letters-010343216.html

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Food & Drink Boulevard in Harlem May 2, 2013 | HarlemCondoLife

Thursday, May 2, 2013 fdba (The Frederick Douglass Boulevard Alliance) invites you to their 2nd annual event: ?Food & Drink Boulevard. ?Summer Kick-Off and Evening of Food, Cocktails, Music and Entertainment on Harlem?s Restaurant Row.

Participants involved this year are:
1) Savann Restaurant
2) Chocolat
3) Bad Horse Pizza
4) Vinateria
5) Cedric
6) Lido
7) Levain Bakery
8) Harlem Tavern
9) Melba?s
10) Harlem Food Bar
11) Bier International
12) 67 Orange Street
13) 5 & Diamond

It will be held from 6pm ? 10pm along FDB up to 123rd Street. Cost is $10 at the door or $5 in advance. Information on tickets

Last years event was a lot of fun with DJ?s, live music, food & drink specials and additional entertainment. ?A great way to start summer off and meet people in your neighborhood. ?Invite your friends, have a good time at your favorite spots!

* Cond? Nast Traveller ?24 hours in Harlem? ? Did your favorite spot make the list?

Follow HarlemCondoLife on Twitter @HarlemHCL Your Gateway To Harlem.

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Source: http://harlemcondolife.com/2013/04/23/food-drink-boulevard-in-harlem-may-2-2013/?utm_source=rss&utm_medium=rss&utm_campaign=food-drink-boulevard-in-harlem-may-2-2013

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Stock index futures indicate higher open

LONDON (Reuters) - Stock index futures pointed to a higher open on Wall Street on Wednesday, with futures for the S&P 500, Dow Jones and Nasdaq 100 futures all up 0.2 percent at 0455 EDT ( 0855 GMT).

U.S. stocks climbed on Tuesday in a broad rally, recovering from sharp declines sparked by a "bogus" Associated Press tweet about explosions at the White House.

Wednesday's diary sees U.S. weekly mortgage market index and durable goods figures. Treasury Secretary Jack Lew also testifies in front of Congress.

Apple Inc on Tuesday bowed to investors' demands to share more of its $145 billion cash pile, while posting its first quarterly profit decline in more than a decade after market close yesterday. The tech giant initially rose in extended trade, then retreated after the company's chief executive suggested there would be no new product in the market for a few months.

KFC parent Yum Brands Inc on Tuesday reported that quarterly profit fell less than Wall Street expected, despite a sharp drop in sales in its top China market, sending the company's shares up nearly 6 percent in after hours trade.

Cable operator Virgin Media posted a 54 percent rise in first quarter free cash flow and announced a series of major business deals on Wednesday, showing the attraction of a company that is about to be sold to Liberty Global.

AT&T Inc reported a net loss of cellphone subscribers in the first quarter as it lost market share to bigger rival Verizon Wireless, sending its shares down about 2 percent in after hours trade.

OPKO Health Inc will buy Israel-based biopharmaceutical company Prolor Biotech Inc in an all-stock deal valued at $480 million to expand its portfolio of specialty drugs.

European shares gained on Wednesday, building on the best session of the year so far on Tuesday. Good earnings reports helped the market higher, while disappointing data from Germany over the last two days has lent strength to the case for the European Central Bank to cut interest rates next week.

(Reporting by Alistair Smout; editing by Patrick Graham)

Source: http://news.yahoo.com/wall-street-jumps-recovery-twitter-led-drop-012743441--sector.html

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3 murder charges against Pa. abortion doc tossed

PHILADELPHIA (AP) ? A judge has thrown out some of the murder charges against a Philadelphia abortion provider involving babies allegedly born alive.

Common pleas court Judge Jeffrey Minehart dismissed three first-degree murder charges Tuesday against Dr. Kermit Gosnell. Minehart has not explained the reasoning behind his ruling.

Prosecutors have argued that the babies were viable and Gosnell and his staff cut them in the back of the neck to kill them.

Defense lawyer Jack McMahon had argued Tuesday "there is not one piece .... of objective, scientific evidence that anyone was born alive" at Gosnell's clinic.

Gosnell still faces charges that he killed a patient and four other babies allegedly born alive.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-23-US-Abortion-Clinic-Deaths/id-605eb437676644fda049233eb68a3b82

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Iron in primeval seas rusted by bacteria

Apr. 23, 2013 ? Researchers from the University of T?bingen have been able to show for the first time how microorganisms contributed to the formation of the world's biggest iron ore deposits. The biggest known deposits -- in South Africa and Australia -- are geological formations billions of years old. They are mainly composed of iron oxides -- minerals we know from the rusting process. These iron ores not only make up most of the world demand for iron -- the formations also help us to better understand the evolution of the atmosphere and climate, and provide important information on the activity of microorganisms in the early history of life on Earth.

The extent to which microbes in the Earth's ancient oceans contributed to the formation of iron deposits was previously unknown. Now an international team of researchers from the US, Canada and Germany has published new findings in the journal Nature Communications. Led by University of T?bingen geomicrobiologist Professor Andreas Kappler of the Center for Applied Geoscience, they found evidence of which microbes contributed to the formation of the iron ores, and were able to show how different metabolic processes can be distinguished in the rock formations today.

The iron in the Earth's ancient oceans was spat out of hot springs on the seafloor as dissolved, reduced ferrous [Fe(II)] iron. But most of today's iron ore is oxidized, ferric [Fe(III)] iron in the form of "rust minerals" -- indicating that the Fe(II) was oxidized as it was deposited. The classic model for the formation of iron deposits suggested that the Fe(II) from the Earth's core was oxidized by the oxygen produced by cyanobacteria (blue-green algae). This process can happen either chemically (as in the formation of rust) or by the action of microaerophilic iron-oxidizing bacteria.

But scientists are still debating at what point the Earth's atmosphere contained enough oxygen (produced by cyanobacteria) to allow the formation of big iron deposits. The oldest known iron ores were deposited in the Precambrian period and are up to four billion years old (the Earth itself is estimated to be about 4.6 billion years old). At this very early stage in geological history, there was little or no oxygen in the atmosphere. So the very oldest banded iron formations cannot be the result of O₂-dependent oxidation.

In 1993, bacteria were discovered which do not need oxygen but can oxidize Fe(II) by using energy from light (anoxygenic phototrophic iron-oxidizing bacteria). Studies by Professor Kappler's team in 2005 and 2010 showed that these bacteria transform dissolved ferric iron into iron oxide (rust) -- like the material in the early iron ores. Now, the geomicrobiologists from T?bingen have been able to demonstrate that, by examining the identity and structural properties of the iron minerals, it is possible to tell that the minerals were deposited by iron-oxidizing microbes and not by oxygen made available by the action of cyanobacteria. To do this, the researchers placed different amounts of organic material together with iron minerals into gold capsules and increased the pressure and temperature to simulate the transformation of the minerals over geological time. They ended up with structures of iron carbonate minerals (siderite, FeCO₃), just as they occur in geological iron formations. In particular, they were able to distinguish iron carbonate structures which had been formed in the presence of a rather small amount of organic compounds (microbial biomass) from those formed in the presence of a larger amount.

This research not only provides the first clear evidence that microorganisms were directly involved in the deposition of Earth's oldest iron formations; it also indicates that large populations of oxygen-producing cyanobacteria were at work in the shallow areas of the ancient oceans, while deeper water still reached by the light (the photic zone) tended to be populated by anoxyenic or micro-aerophilic iron-oxidizing bacteria which formed the iron deposits.

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The above story is reprinted from materials provided by Universitaet T?bingen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Inga K?hler, Kurt O Konhauser, Dominic Papineau, Andrey Bekker, Andreas Kappler. Biological carbon precursor to diagenetic siderite with spherical structures in iron formations. Nature Communications, 2013; 4: 1741 DOI: 10.1038/ncomms2770

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/Zix1TcAv23I/130423110750.htm

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Anonymous Hits Israel with a Massive Cyber Attack, Israel Attacks Back

To ring in this year's Holocaust Memorial Day, the classy hackers at Anonymous took down a bunch of Israeli government websites on Sunday and say they caused over $3 billion in damage. But they didn't totally get away with it. Within a few hours of the attack which Anonymous says affected 100,000 websites, 40,000 Facebook pages, 5,000 Twitter accounts and 30,000 bank accounts, an Israeli hacker broke into the website that Anonymous had set up for the attack, dubbed Operation Israel. Instead of the original anti-Israel messages that were originally on the site to protest Israel's treatment of Palestine, the Israeli hacker rejiggered the site to play "Hatikvah," Israel's national anthem.?

RELATED: Hackers Discover Government Employees Watch Porn

Israel's playing this one super cool. Despite Anonymous's claims of massive damage, the country's cyber security officials say that the attack caused minimal damage. "So far it is as was expected, there is hardly any real damage,"?Yitzhak Ben Yisrael from the government's National Cyber Bureau told the press. "Anonymous doesn't have the skills to damage the country's vital infrastructure. And if that was its intention, then it wouldn't have announced the attack ahead of time. It wants to create noise in the media about issues that are close to its heart." This is more or less what Anonymous always does, often with varying levels of success.

RELATED: LulzSec Document Release Targets Arizona Law Enforcement

Regardless of the amount of damage done, the scale of the attack is bound to be embarrassing for the Israeli government. This is the second time that Anonymous has successfully taken down Israeli government websites. The original #OpIsrael attack happened last November and affected some 600 sites and resulted in the hackers released personal information for thousands of high-ranking officials. Israel denied then that the attack did any damage, and some tech writers balked at the effort, saying that Anonymous had lost its swagger.

RELATED: Hackers Respond to Hacking Arrests with More Hacking

If that was the case then, Anonymous just looks insensitive now. The Holocaust and any holiday commemorating it is hardly a topic to goof around about. And given Israel's allege involvement in the infamous Stuxnet cyber attack, it's hard to believe a bunch of zany hackers with a bad DDoSing habit could really stand up to their security teams. They didn't either.?

Source: http://news.yahoo.com/anonymous-hits-israel-massive-cyber-attack-israel-attacks-005659174.html

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Leaked Galaxy Mega 5.8 specs seem to confirm mid-range leanings

5.8-inch qHD display, dual-core Exynos CPU

It's around a week since we first heard of the Samsung Galaxy Mega series -- supposedly two big-screened devices due to launch later this year. Now oft-reliable Samsung rumormonger SamMobile says it has more details on exactly what kind of hardware will be found within the 5.8-inch variant (GT-i9152), and unfortunately for those hoping for a Galaxy Note 2 successor, it's a rather mid-range affair.

The Galaxy Mega 5.8 is said to pack a dual-core Exynos CPU, a qHD (960x540) resolution LCD display, 1.5GB of RAM and an 8-megapixel rear camera. Other vital stats include a 2600mAh battery and dimensions of 164x83.8x9.7mm; on the software side it's TouchWiz'd Jelly Bean running the show.

With the exception of the screen, that's pretty close to the internals of the original Galaxy Note, which is nothing to sniff at. But we're unconvinced by the prospect of qHD on a screen of that size. As reported last week, the Mega 5.8 will supposedly come in single and dual-SIM variants.

No word yet on how the rumored Galaxy Mega 6.3 will compare, but our money is on similarly middling specs.

Source: SamMobile

Source: http://feedproxy.google.com/~r/androidcentral/~3/6uZcqYEnC9o/story01.htm

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AACR news: New target plus new drug equals death of melanoma cells

Public release date: 9-Apr-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Mer is overexpressed in melanoma and the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them

Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research (AACR) Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them.

"It's exciting in that Mer receptor expression correlates so perfectly with disease progression. It's tiered you see a bump in expression as you transition from nevus to melanoma and then again as you transition from melanoma to metastatic disease," says Doug Graham, MD, PhD, investigator at the CU Cancer Center and associate professor of Pediatrics and Immunology at the University of Colorado School of Medicine, the paper's senior author.

After proving this correlation between Mer receptor expression and disease stage in melanoma tissues from clinical patient samples, Graham and colleagues wondered what would happen if they interrupted this Mer signaling. Luckily, the University of North Carolina had recently developed a new compound that did just that UNC1062. The results were dramatic.

"We showed decreased survival signaling, increased apoptosis and decreased growth of the melanoma cells in dishes and in mouse models," Graham says. It seems that Mer receptors are not only correlated with melanoma progression but are in fact driving the aggressiveness of the disease.

"This is the first time there's been an association between Mer and melanoma and the first time to report about this new drug," Graham says.

###

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[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 9-Apr-2013
[ | E-mail | Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Mer is overexpressed in melanoma and the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them

Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research (AACR) Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them.

"It's exciting in that Mer receptor expression correlates so perfectly with disease progression. It's tiered you see a bump in expression as you transition from nevus to melanoma and then again as you transition from melanoma to metastatic disease," says Doug Graham, MD, PhD, investigator at the CU Cancer Center and associate professor of Pediatrics and Immunology at the University of Colorado School of Medicine, the paper's senior author.

After proving this correlation between Mer receptor expression and disease stage in melanoma tissues from clinical patient samples, Graham and colleagues wondered what would happen if they interrupted this Mer signaling. Luckily, the University of North Carolina had recently developed a new compound that did just that UNC1062. The results were dramatic.

"We showed decreased survival signaling, increased apoptosis and decreased growth of the melanoma cells in dishes and in mouse models," Graham says. It seems that Mer receptors are not only correlated with melanoma progression but are in fact driving the aggressiveness of the disease.

"This is the first time there's been an association between Mer and melanoma and the first time to report about this new drug," Graham says.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/uocd-ann040613.php

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Weak economic reports send stock market lower

NEW YORK (AP) ? Weak reports on hiring and service industries sent the stock market sharply lower Wednesday, giving the Dow Jones industrial average its worst day in more than a month.

The Dow fell 111.66 points, or 0.8 percent, to 14,550.35, its worst decline since Feb. 25. The Standard & Poor's 500 index dropped 16.56 points, or 1.1 percent, to 1,553.69. Both indexes closed at record highs the day before.

The stock market started 2013 with a rally as investors became more optimistic about the U.S. economy, especially housing and jobs. The reports Wednesday disappointed the market and came two days after news that U.S. manufacturing growth slowed unexpectedly last month.

The losses were widespread. All 10 industry groups in the S&P 500 index fell. Banks and energy stocks had the worst losses, 1.7 percent and 1.6 percent. Utilities, which investors hold when they want to play it safe, fell the least, 0.3 percent.

"The market is overdue for a correction," said Joe Saluzzi at Themis Trading. "I don't think that the economy supports this type of a rally."

Signs of investor skittishness appeared across a number of different markets.

Commodities slumped. Crude oil dropped $2.74, or 2.8 percent, to close at $94.45 a barrel and industrial metals like copper fell.

The yield on the 10-year Treasury note fell to 1.81 percent from 1.86 percent, the lowest level for the benchmark rate since January. The decline means investors are moving money into low-risk U.S. government debt.

The Russell 2000 index, which tracks small company stocks, fell for a third straight day, dropping 1.7 percent. It's now down 3.5 percent so far this week, far worse than the declines in the Dow, 0.2 percent, and the S&P, 1 percent. That's another signal that investors may be becoming more bearish about the U.S. economy.

Small company stocks, which did better than the Dow and the S&P 500 in the first three months of the year, are more sensitive to the outlook for the U.S. economy than the larger companies in the Dow and S&P. That's because they rely far more on domestic sales than global giants like IBM and Caterpillar, which sells heavy machinery and construction equipment around the globe.

The Dow Jones Transportation Average, an index of 20 stocks including airlines like Delta and freight companies FedEx and UPS, fell more than 1 percent for a third straight day. The index, which is regarded as a leading indicator for broader market indexes as well as the economy, has fallen 3.9 percent this week, after surging 17.9 percent in the first quarter.

U.S. service companies kept growing at a solid pace in March, but the expansion was less than economists were expecting. The Institute for Supply Management's index of service companies fell to 54.4 from 56 a month earlier. The report was the weakest in seven months.

Separately, payrolls processor ADP reported that U.S. employers added 158,000 jobs last month, down from February's gain of 237,000. The ADP report is often seen as a preview for the government's broader survey on employment, which is due out Friday.

The slowdown in hiring was due in part to construction firms holding back on adding new employees. That sent the stocks of homebuilders lower. PulteGroup fell 85 cent, or 4.3 percent, to $19.01 and D.R. Horton dropped 57 cents to $22.84.

In other trading, the Nasdaq composite fell 36.26 points, or 1.1 percent, to 3,218.60.

Even though stocks started the second quarter lower, markets typically add to their gains after ending the first quarter up, said Sam Stovall, an equity strategist at S&P Capital IQ. Using data going back over more than 60 years, Stovall says that the S&P 500 has gained an average of 9 percent from April to December after rising in the first quarter.

"Investors believe that the economic trajectory is improving," said Stovall. Stocks "do not reflect the true valuations based on where the economy will be at the end of the year."

Among stocks making big moves:

? Zynga rose 46 cents, or 15 percent, to $3.53 after the online game maker said two casino games would debut in the United Kingdom Wednesday.

? Abercrombie & Fitch rose $1.74, or 3.8 percent, to $47.20, making it the biggest percentage gainer in the S&P 500. The company said late Tuesday that it planned to expand internationally and place greater emphasis on cost control.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-03-Wall%20Street/id-6c21d71c6d3a4c9faecf733bcedaa045

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Nigeria stocks rise to 1-month high on Dangote Cement

PARIS, April 2 (Reuters) - Paris St Germain 2 Barcelona 2 - Champions League quarter-final, first leg result At Parc des Princes Scorers: Paris St Germain: Zlatan Ibrahimovic 79, Blaise Matuidi 90+4 Barcelona: Lionel Messi 38, Xavi 89 penalty Halftime: 0-1; Teams: Paris St Germain: 30-Salvatore Sirigu; 26-Christophe Jallet, 13-Alex, 2-Thiago Silva, 17-Maxwell; 29-Lucas, 32-David Beckham (24-Marco Verratti 70), 14-Blaise Matuidi, 27-Javier Pastore (19-Kevin Gameiro 76); 18-Zlatan Ibrahimovic, 11-Ezequiel Lavezzi (7-Jeremy Menez 66) Barcelona: 1-Victor Valdes; 2-Daniel Alves, 3-Gerard Pique, ...

Source: http://news.yahoo.com/nigeria-stocks-rise-1-month-high-dangote-cement-135001318--finance.html

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Mark Sanford Just Won The Republican Runoff In ... - Business Insider

Former South Carolina Gov. Mark Sanford ? whose political career was thought to have ended with his Appalachian Trail fib four years ago ? began his comeback Tuesday night, winning the Republican nomination in the race for the state's 1st Congressional District, the Associated Press reports.

Sanford will now face off in a general election contest against Democratic nominee Elizabeth Colbert Busch, the sister of faux-conservative comedian Stephen Colbert.

Early polls indicate that the race will be close. Although South Carolina's 1st district is very conservative, Colbert Busch appears to have a real chance of pulling off an upset, due, in part, to her national name recognition.

?I look forward to a vigorous campaign that focuses on creating jobs, balancing our country?s budget and choosing an independent-minded leader who shares the values of the great people of South Carolina,? Colbert Busch said in a statement shortly after Sanford's win.

Democrats are also likely to benefit from Sanford's unsavory past ? namely, the highly-publicized 2009 revelation of an extramarital affair with a woman in Argentina, which came to light when he disappeared from the governor's office for several days. Aides told the press Sanford had gone for a solitary hike on the Appalachian Trail, when in reality, he was visiting his mistress. Sanford, now divorced, is engaged to his former mistress.

Source: http://www.businessinsider.com/mark-sanford-stephen-colbert-sister-elizabeth-south-carolina-election-2013-4

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Bravo's ''Real Housewives of Atlanta'' Finale Caps Off Most-Watched Season

By Jethro Nededog

LOS ANGELES (TheWrap.com) - Yet another dramatic sparring between show newbies Kenya Moore and Porsha Stewart attracted big increases for Bravo's "The Real Housewives of Atlanta."

Sunday's episode attracted more than three million total viewers. The Season 5 finale saw a 33 percent increase over last season's finale among the advertiser-coveted 18-49 demo (about 1.9 million viewers).

The fifth season, which also saw the departure of original castmember Kim Zolciak, has averaged more than three million viewers an episode, a seven percent increase over last season.

With this season's numbers, "RHOA" holds its position as not only the franchise's most-watched city, but also the network's most-watched series. "The Real Housewives of New Jersey" is Bravo's second most-watched series of the franchise.

In light of the show's success, Bravo has announced a three-part reunion, with part one kicking off next Sunday at 8 p.m., followed by a "Secrets Revealed" special, which basically sounds like its usual "lost footage" episode.

Source: http://news.yahoo.com/bravos-real-housewives-atlanta-finale-caps-off-most-010459977.html

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'American Idol' ouster is no surprise

By Craig Berman

Jimmy Iovine called the Devin Velez-Lazaro Arbos-Burnell Taylor trio ?Wrong Direction? after their group performance on Wednesday.? It turns out that it?s more like the overarching theme for the guys in season 12.

For the second time in three weeks,? the bottom three was an all-male affair, and for the third week in a row it was a guy who got shown the door.? This time the bell tolled for Devin, though the judges sold the possibility of a save for all they were worth, as though the ?A Girl Must Win? season 12 storyline would allow for that sort of shenanigans. The crowd chanted, the judges appeared to be glancing at each other like it was actually under consideration ? but Randy Jackson was the Grinch who Stole ?Idol? and Devin went home.

No big shock. Devin was better this week, but as Jimmy noted that was in comparison to his previous efforts, not in relation to how everyone else did. His farewell performance featured the English-Spanish mix that impressed Nicki Minaj so much back in the day, but it was all for naught.

Fox / Getty Images Contributor

Devin Velez was sent home.

Even worse news for those who were betting on the "Idol" men this season -- Lazaro was in the bottom two.? He?s the guy who could do no wrong with the voters despite subpar performances, so the fact that he was in the danger zone after a much better solo effort this week doesn?t bode well for the guys. It?s the rare time when a group performance could prove to be a game-changer -- he was so terrible when paired with the other guys that it might have closed a few eyes, or shut down a few phone lines.

As for Burnell, he was the first guy sent to safety, which this season is akin to Jack Dawson winning that last seat on the Titanic. He?s now the odds-on favorite to finish sixth.

It was also a bad night for those who like their results shows to feature actual results. It was a full 47 minutes before anyone heard their fate, by which point we?d heard Colton Dixon, Katharine McPhee and One Republic, and Keith Urban perform live, the ?Idol? contestants do another brutal group number and mentor young children in how to sing like season 11 champion Phillip Phillips, and Jimmy give his detailed thought on every Wednesday performance, including the group acts. ?Idol? continues its groundbreaking efforts to kill time and sell commercials, but I do not think the phrase ?results show? means what Fox thinks it means.

It was a banner night for the girls, particularly Kree Harrison, who got the patented Voicemail of Praise from Aretha Franklin. Sure, Jimmy said that Angie Miller maybe shouldn?t pick her own songs any more and was off-track, but she still was among the top five vote-getters.

That all ends next week, however.? It?s a sure bet that one of the women will be among the three contestants with the fewest votes.

Because there are only two guys left.

Did you agree with the ouster? Tell us on Facebook.

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Magic Johnson's Son Comes Out as Gay, Receives Support from Father

Source: http://www.thehollywoodgossip.com/2013/04/magic-johnsons-son-comes-out-as-gay-receives-support-from-father/

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Jane Henson Dead: Co-Creator Of The Muppets Dies At 78

LOS ANGELES ? The Jim Henson Co. says Henson's partner in marriage and Muppets has died.

The company says Jane Henson died Tuesday at her Connecticut home following a battle with cancer. She was 78.

She and Jim Henson met in a University of Maryland puppetry class in the mid-1950s, and they became creative and business partners in the development of the Muppets.

The Hensons married in 1959 and had five children: Lisa, Cheryl, Brian, John and Heather. The pair separated in 1986, and Jim Henson died in 1990.

In 1992, Jane Henson created and funded The Jim Henson Legacy to preserve his artistic contributions.

A memorial Mass is planned next week.

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Source: http://www.huffingtonpost.com/2013/04/02/jane-henson-co-creator-of-muppets_n_3003055.html

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